Effects of plant extract powder supplementation on lipopolysaccharide-induced sepsis and hepatic and kidney antioxidant capacity in Wistar rats

Authors

  • Chatarina Lilis Suryani Universitas Mercu Buana Yogyakarta, Faculty Agroindustry, Department Food Technology, JL Wates KM 10 Yogyakarta, 55753, Indonesia, Tel.: +6282322287879 , Mercu Buana University of Yogyakarta image/svg+xml Author
  • Ferry Irawan Ladira Homecare, JL Kesehatan Raya No 20 Bintaro Jakarta Selatan, 12330, Indonesia, Tel.: +6281318776421 Author
  • Yuli Perwita Sari Universitas Mercu Buana Yogyakarta, Faculty Agroindustry, Department Animal Husbandary, JL Wates KM 10 Yogyakarta, 55753, Indonesia, , Mercu Buana University of Yogyakarta image/svg+xml Author
  • FX Suwarta Universitas Mercu Buana Yogyakarta, Faculty Agroindustry, Department Animal Husbandary, JL Wates KM 10 Yogyakarta, 55753, Indonesia, Tel.: +6282221462651 , Mercu Buana University of Yogyakarta image/svg+xml Author
  • Umul Aiman Universitas Mercu Buana Yogyakarta, Faculty Agroindustry, Department Agrotechnology, JL Wates KM 10 Yogyakarta, 55753, Indonesia. , Mercu Buana University of Yogyakarta image/svg+xml Author
  • Ichlasia Ainul Fitri Universitas Mercu Buana Yogyakarta, Faculty Agroindustry, Department Food Technology, JL Wates KM 10 Yogyakarta, 55753, Indonesia, Tel.: +6282322287879 , Mercu Buana University of Yogyakarta image/svg+xml Author

DOI:

https://doi.org/10.5219/scifood.79

Keywords:

sepsis, LSP, supplements, antioxidants, liver, kidney

Abstract

Controlling inflammation caused by bacterial invasion or toxic compounds is crucial to preventing sepsis. Supplements containing phenolics, flavonoids, vitamins, chlorophyll, and peptides can serve as sources of antioxidants to help control inflammation. Bforliefe supplement diet (BSD) is a powdered drink supplement made from 29.3% peach fruit concentrate, strawberry powder, mulberry extract powder, guava powder, broccoli powder, acai berry fruit extract, soy protein powder, moringa leaf extract, inulin, ascorbic acid, stevia sweetener, algae, and a vitamin and mineral premix. In this study, BSD was administered to male Wistar rats for 14 days, with vitamin E as a comparison. 20 rats were divided into 4 experimental groups consisting of G1: normal rats, G2: negative control, G3: group of rats with vitamin E intake of 80 mg/200 g body weight, and G4: group with BSD intake at a dose of 270 mg/200 g body weight. The G2-G4 rat groups were treated with LPS (10 mg/kg body weight) for 3 days after a 7-day adaptation period. The effects of supplement intake were evaluated using parameters such as malondialdehyde (MDA) levels in blood serum, kidney and liver homogenates, production of interleukin-6 (IL6), interleukin-10 (IL10), and tumor necrosis factor-α (TNF-α), and antioxidant capacity including Superoxide Dismutase Activity (SOD), serum hormone Glutathione (GSH), and Catalase Activity (CAT). The research results showed that BSD exhibits DPPH radical-scavenging activity and an IC50 comparable to that of commercial vitamin E. The administration of BSD supplements for 14 days in male Wistar rats induced by LPS was able to normalize weight gain, reduce MDA levels, decrease IL-6 and TNF-α production, increase serum IL-10 levels, and enhance the antioxidant capacity of SOD and CAT in liver and kidney tissues. BSD supplements are potential sources of antioxidants that can mitigate sepsis induced by LPS.

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Effects of plant extract powder supplementation on lipopolysaccharide-induced sepsis and hepatic and kidney antioxidant capacity in Wistar rats. (2026). Scifood, 20(1), 227-243. https://doi.org/10.5219/scifood.79

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